I hear a lot of frustration from Remdesivir victims and their families, and no wonder. The government has turned a blind eye to a Holocaust in the United States. If you’re looking for something to do that might be helpful, here’s a suggestion. Contact Victoria Yan and ask her to help explain how Remdesivir kills people. She seems to be a real expert on it.
Under other circumstances, I wouldn’t do this. It could be considered harassment or bullying. But let’s get real. There is in fact a Holocaust that has been going on in hospitals in the United States since 2020, that has claimed millions of lives, that is still going on.
You know, I remember talking about the Holocaust in school. The conversation was, what would you have done? Everyone said they wouldn’t have gone along with it. Now look. The people of the United States have all become a bunch of God-Damned cowards and idiots. So if I have to hurt some feelings to change the world, you better believe I’ll do it. I’ll do more than that if I have to. Enough of this murder program. I want them to die for a change, not us.
If you want to use Due Process, the Rule of Law, we need to get the experts on our side. I’ve tried being polite. I’ve tried asking Yan questions on Twitter. She won’t reply.
Maybe she will reply to you. Maybe offer to fundraise for her if she will join the side of the victims and renounce the criminals. She seems to be available for hire, if you can outbid the competition, or make them feel guilty enough about the Remdesivir murder program to change sides. Yan and Muller thanked “Steve Kirsch and the COVID-19 Early Treatment Fund (CETF) for financial support” in their March 18, 2021 paper: “Remdesivir for COVID-19: Why Not Dose Higher?”
Yan, Muller, Kirsch, et al, are currently advocating for authorization of another Gilead compound, GS-441524, when they should be calling for an immediate suspension of Remdesivir and criminal prosecutions of the guilty individuals.
As a citizen of the United States, I demand that employees at Gilead Sciences, the FDA, the NIH, and every other agency or corporation involved in this Remdesivir murder program face the death penalty. Gilead should be liquidated and all the proceeds should be turned over to Remdesivir victims and their families.
It’s a sad fact that agencies like the FBI have also become controlled by this nameless globalist criminal organization, which has been described at times as the Rothschild banking dynasty, globalists, the illuminati, or transnational organized crime network. You can look at the history of the FBI and see how they did their job once, though. They start at the bottom and get the small fish to provide evidence on the higher levels. We’re going to have to do it ourselves, that is if you want to maintain Due Process and Rule of Law, but honestly something has to give. Enough.
Victoria Yan is or was a graduate student at MD Anderson Cancer Center in Houston, Texas. She has co-published several papers with Florian Muller of Muller Lab about Remdesivir and GS-441524. Florian Muller:
Let’s take a look at Yan’s callous use of the word “cyanide.” Victoria Yan uses the name “victoriacyanide” on Twitter.
Victoria used the email address “victoriacyanide@gmail.com” in Yan and Muller’s June 23, 2020 paper “Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.”
Victoria’s uses the name @VICTORIACYANIDE on Substack. https://substack.com/@victoriacyanide
We need experts in the United States to explain exactly how Remdesivir is deadly. Even if I give myself a crash education in chemistry, I still wouldn’t be on her level. Still though, when it comes to Remdesivir and cyanide, between Yan’s callous use of the word, and an article written in France about Remdesivir and cyanide, it’s obvious that Remdesivir has cyanide-like effects.
The most informative and easy to read article on Remdesivir and cyanide at my level of understanding is from France: Did the Gilead company hide the true toxicity of Veklury © (remdesivir)? This is going to be disturbing. It was for me anyway.
Look at the compounds GS-5734 (Remdesivir) and GS-441524 side by side. GS-441524 a “metabolite” of Remdesivir, what’s left of Remdesivir after it breaks down a bit.
You have to realize that Veklury (remdesivir) (GS5734) is a prodrug, which means that once metabolized in the body, it will break down to give the active molecule, identified as GS-441524.
I circled the area on the left because Victoria uses this molecular group for her “molecular Sherlock” icon. I’m not sure if this circled area is a cyanide-like group or not. This molecular structure is in GS-5734, but is not in GS-441524.
A cyano group (—C=N) is considered a carbon atom with three single bonds to a nitrogen atom and as a nitrogen atom bonded to three carbon atoms.
Anyway, that’s the kind of question I’d like Yan to answer. I’ve asked her about it on Twitter. She has not replied to me, (can you hear me now?), but I hope if enough of you question her about it, she will reply to you.
Back to the French article on Remdesivir and cyanide. Again, I caution this may be upsetting to read, because it tells it like it is.
Nitriles are very well known to chemists. These are very reactive and very often toxic molecules. They are also used in the chemical industry to make insecticides, pesticides, powerful detergents for hard-to-scour materials such as metals.
Nitriles are cyan compounds. This class of compounds is characterized by the presence of a C≡N group (cyanide) and includes cyanides and nitriles (R – C≡N), as well as related chemical compounds such as cyanogen’s, isocyanates and cyanamides. They owe their toxicity mainly to the cyanide ion which, when released in the body, is capable of inhibiting many enzymes, in particular cytochrome oxidase. Death, which occurs more or less quickly depending on the speed of release of the cyanide ion, is the result of chemical asphyxiation at the cellular level.
Nitriles or organic cyanides are therefore organic compounds characterized by the presence of a cyanide functional group (–C≡N) whose general formula is RCN. They can be considered as hydrocarbon derivatives in which three hydrogen atoms linked to a primary carbon atom are replaced by a Nitrile group or by derivatives of carboxylic acids (R – COOH) in which the oxo and hydroxyl radicals have been replaced by a Nitrile group (– C≡N). By hydrolysis, they give an acid which contains the same number of carbon atoms and it is by this analogy that they are usually called hydrocyanic acid, rather than as derivatives of hydrogen cyanide. Nitriles are very dangerous compounds because they release hydrogen cyanide when they decompose under the effect of heat. …
Indeed, we note that the warnings in the manufacturers' instructions (14) alert to the significant toxicity of the product: acute toxicity, corrosion / irritation of the skin, serious eye damage / irritation, respiratory or skin sensitization, germ cell mutagen, reproductive toxicity, specific target organ toxicity (single exposure), specific target organ toxicity (repeated exposure). We find absolutely all the potential damage that we find in the most toxic nitriles which there is no need to recall their sinister use as combat gas.
What do we know about altrononitriles? Very little. Cyanide agents have a long military history. Since the First World War, they have come in many forms and have proven to be formidable chemical weapons, like the Zyklon B.
Zykon B is hydrogen cyanide, used against Jews in concentration camps in Germany. They were told that they were taking showers and walked right in there. I know it’s disturbing but you need to understand what happens when people trust blindly for too long, and criminals in government and corporations become above the law over time. It happened again. They actually used cyanide again.
Back to Victoria Yan and Florian Muller. They’re on the wrong side right now, supporting Gilead. As they stated, they have been funded by Steve Kirsch and the CETF. Kirsch and CETF are not on the side of the American public. If they were, they would be calling for the immediate suspension of Remdesivir, not advocating for the use of another Gilead product.
Yan and Muller have a lengthy history of supporting GS-441524 over GS-5734. Some of it I will outline. This is not intended to be a full review. One of the most stupid and ridiculous aspects of their support is the “dead cats” study, which I will cite. I recommend the reader click on the links and read them. Again, Yan and Muller are very informed, and very misguided about what they need to be doing with their educations.
May 2020. LETTERS TO THE EDITOR (Chemical and Engineering News). June 18, 2021. Victoria Yan, Houston
In May 2020, Florian Muller, Steve Kirsch, the scientific advisers at the COVID-19 Early Treatment Fund, and I communicated to the Gilead leadership the several advantages that GS-441524 possesses over remdesivir. These include being orally administrable; significantly safer, which enables up dosing; and easier to synthesize. Despite presenting compelling data, we encountered an unwillingness to proceed with GS-441524 development.
May 14, 2020. Yan and Muller write: Gilead should ditch remdesivir and focus on its simpler and safer ancestor in Stat News.
Remdesivir’s lackluster results in patients with advanced Covid-19 in the NIAID-sponsored trial and the finding that it provided no statistically significant benefit in a clinical trial conducted in China among patients with severe Covid-19 symptoms are likely due to the suboptimal level of active GS-441524 triphosphate in the lungs. Patients with advanced or severe Covid-19 generally have a high viral load in their lungs and would need a high concentration of GS-441524 triphosphate to combat it. The benefit of using GS-441524 over remdesivir is that GS-441524 can almost certainly be given at much higher doses due to its lower toxicity. This would result in more conversion to the active compound, GS-441524 triphosphate, in the lungs.
June 23, 2020. Yan and Muller publish Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.
On August 4, 2020, Yan and Muller co-signed a letter with “Public Citizen” addressed to Daniel O’Day, CEO of Gilead, Stephan Hahn, Commissioner of FDA, Gary Disbrow, Director of BARDA, Anthony Fauci, Director of NIAID, and Francis Collins, Director of NIH. Arguing for GS-441524, of course.
In this letter, as Yan has done several times, they base their support of GS-441524 on a few small cat studies of Feline Infectious Peritonitis (FIP), or feline coronavirus. “GS-441524 has demonstrated marked efficacy and safety in the treatment of a deadly coronavirus infection in cats.” 7 out of these 35 cats, or 20% of the cats, died after receiving GS-441524. Those are the kinds of results that only the FDA and someone who calls herself Victoria Cyanide could love. I’ve noted my objections to Yan on Twitter about her absurd support for GS-441524 based on these deadly studies in cats. I bet Ivermectin would have worked. She has not responded.
August 9, 2020. Steve Kirsch says that Yan and Muller’s paper is VERY important. He says GS-441524 is superior to Remdesivir in every way. He doesn’t say that Remdesivir should be suspended immediately. Remember that the 53% death rates of the 2018-2019 Remdesivir Ebola study were already public. This is the kind of thing you see from “philanthropy” influenced by the likes of Bill Gates and the Rockefellers. Always pretending to look for that magic bullet, while committing mass murder every step of the way.
Steve mentioned the “dead cats” study. You can read the dead cats parent study by Pedersen et al here: Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis.
Results
Four of the 31 cats that presented with severe disease died or were euthanized within 2–5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment. Eighteen of these 26 cats remain healthy at the time of publication (OnlineFirst, February 2019) after one round of treatment, while eight others suffered disease relapses within 3–84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy at the time of publication. However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy.
And this is the good stuff, according to Yan, Muller, and Kirsch. 24 out of 31 cats are still alive! This isn’t the bad stuff, Remdesivir. It’s not the same virus, not the same species, and it’s deadly, but it’s probably better than Remdesivir. Philanthropist says: HOT DAMN, let’s do it! The FDA should love this one! “With friends like that….”
SUMMARY
I suppose that’s enough. You should have the picture. First of all, Remdesivir should be stopped. If she wants to be on Gilead’s side, so be it, but when Justice finally does wake up she will be terribly vengeful. It’s infuriating that people like Yan can use the word “cyanide” in the manner she does, while millions of people around the world are murdered with it, and she thinks nothing of it. People like Yan and Muller have been conditioned to believe that the government won’t do anything to the medical community, because they believe the medical community has a license to kill and lie for profit. But they do not. I don’t know what it will take to change her mind, but if you want to give it a try, you have their contact information.
Charles Wright
So, if I were to provide some criticisms, there's honestly quite a few issues I have with this article. First off, what was circled in red is a phenyl group that's part of the remdesivir's protection group. As you mentioned the cyano group is a C triple bonded to an N. The actual cyano you are looking for is on the C1' position of the sugar (right below the adenosine).
Nucleoside analogues have prodrug groups to stop them from being metabolized. One of the problems is that Gilead was concerned about the rate limiting step during the phosphorylation process, which they assumed to be the addition of the first phosphate. There's really no evidence that the first phosphorylation is the limiting step on the way to forming the triphosphate, but Gilead instead decided to include the monophosphate form anyways. The problem now is that you need protecting group so that nucleases don't metabolize the monophosphate, so all of those groups, including the phenyl group you circled, were added to prevent it from being quickly metabolized. It also removed the negative charges which changes how the drug is administered.
That whole group is called a McGuigan Protide, or a ProTide for short. This protection group as a lot of different problems, but it appears that one of the biggest problems is that it requires multiple more steps in order to remove the functional groups before the other phosphates can be added.
It appears the argument they are making is that you can just bypass all of those unnecessary steps and just administer the nucleoside form. I haven't looked into how this affects metabolism, but regardless no matter which way you look at it all of these forms have a cyano group. It's this cyano group that is argued to provide the drug its mechanism of action.
There are Gilead posters in trains in Brisbane promoting HIV - let’s talk about it
Next round of drugs must be ready to deploy