Interesting article Charles, but I don't think they are blind. At Vanderbilt they have done enough research projects it should have become evident pretty quickly that one therapy was causing death and one therapy was improving the patient's condition. The problem is that all of the educational programs have been captured by the liberal woke gestapo and are turning out a generation of robots who march in lockstop to orders. This week I received my quarterly newsletter from my state nursing association. Even though I retired my license in 2020, I'm still on the mailing list. It talked about how they are now lobbying the state legislature to pass three main bills. #1 - Workplace safety and violence prevention. #2 - Decriminalization of nurses. #3- Nursing shortage. My head about exploded. First of all, workplace safety and violence? Where is the data that nurses are being attacked in the hospitals? Why have they suddenly become the victims? If there has been an increase in violence maybe it's because they isolated patients from their families, threatened them with arrest by the police and violated patient's basic civil rights. Second, decriminalization of nurses? They say this is needed because criminalization of medical errors causes a decrease in reporting. They also say this would not free them from liability due to misconduct or civil liability. No, the federal government did that for them so they could freely murder without any worries about being held responsible. Unbelieveable. And finally, the nursing shortage. They state since the pandemic there is a critical shortage that is greater than even projected in 2014. Gee, I wonder why? Couldn't be that vaccine mandate they went all in on could it? Or maybe the nurses who were independent thinkers refused to be a part of the genocide they saw being carried out. Either way, you reap what you sow. So here you have the "leaders" of the statewide nurses so lacking in self-awareness that they can't even see how they have contributed to their own problems. They also included a quote from a Gallup poll that stated the nursing profession scored the highest assessment when it comes to ethics and honesty. What they failed to include is that assessment has dropped 10 points from it's highest rating in 2020. I hope they do try to push through the bill giving them protection from criminal liability. I will be the first one to line up and testify against passage of the bill, and I will make sure I will have plenty of other witnesses there with me.
You know, I'm still giving reasonable doubt to some of the lower level employees in all of this, but if they knew they were killing people, that's just illegal and there is a price to be paid for it. Thank you for your perspective.
I will say that my daughter said there was one nurse that worked the last night she was there who was sweet and kind and when she brought in the Remdesivir and tried to give it my daughter said 'No, I don't want that" forcefully to her, she said, OK, that's fine and laid it down and didn't even question it. She was also the first nurse in 3 days to ask her about washing up or if her sheets had been changed or freshened up and that actually spent time with her. One day she went 10 hours without seeing a nurse. She told the nurse before she left her room she was the only one on that floor that actually acted like she cared about patients. So it may not take everyone to be evil, but enough of them to start the crime and the rest may not realize they are accessories. The one disconnect we did find was between the nursing staff and Respiratory therapy staff. Nursing kept turning her oxygen up to ridiculous, uncalled for amounts and at one point had her on 15 liters and told her the next step was a ventilator because she couldn't go any higher with a regular face mask. Now mind you she was not short of breath, could take it off herself and get up and walk to the bathroom just fine. They had ordered a nebulizer on admission and 2 days later it still had not been given to her. She hadn't seen a Respiratory therapist in over 36 hours. Well , it just so happened her boss was really good friends with the CEO of the hospital and had told her if she needed anything at all to let him know. I told her it was time to play that card so she called him. Within 5 minutes she had 2 RT supervisors in her room and that's when things began to turn around. They got her nebulizer set up (which nursing had never sent the order through), they turned her monitor around so she could see what her oxygen level was running and they turned her O2 back down to 6 liters because her levels were in the 90's. In fact ,one of the RT supervisors was stunned they had her on that much oxygen. She told him she had been asking the nurses to turn it down but they said they were only allowed to turn it up not down. He told her that wasn't true. So Respiratory Therapy certainly knew that something wasn't right. But whether they thought it was just people bad at their job or more sinister is hard to say. But these 2 individuals helped save her life. Because she could now monitor her oxygen level, I was able to have her start weaning off the oxygen and that's how we were able to get her to walk out of there AMA. I had lunch with a couple of nurse friends I worked with for years a few months ago. We were so close for years, and knew each other's most intimate secrets, our children were all the same ages and played together. I trained them when they first started so they've always considered me their mentor. I've supported one of them through a divorce, you know the kind of friends you may not see for 5 years, but then when you see again it's like you haven't been apart for a day. They both still work part time in the hospitals. As I began to tell them about our experience in the hospital, they looked at me with their mouths open like I had grown a second head. I could tell they thought I must be making this up, it couldn't have happened like I was saying. I left with a profound sadness that day, because I knew nothing would ever be the same again. Then I remembered something one of them had said the previous time we had met before this. She had said how they were offering such big bonuses to get nurses to work extra shifts. Then she said, they even gave us all $50 Kroger gift cards just to be nice, and was almost giddy when she said it. Yeah, I thought, how many patients did they have to murder to pay for those. It was obvious she didn't have a clue.
So well written. I am a nurse as well. I am retired and I am ashamed of my profession who stood by and watched these patients die. I don’t know how they can live with themselves when innocent, sick people only came for help. It will take years for people to trust nurses and doctors again.
Interesting idea of "no one blind" comparisons. Although the Pharmas would game that just like remdesivir v hydroxy. With the vaxxxes the trials and data were a total farce as per the Brook Jackson case. The reg agencies are totally captured! So all data are now pure jokes.
Let me ask you a question: What is conditional power analysis, and how do you think it was used in the context referenced in the ORCHID hydroxychloroquine trials at Vanderbilt? Here is the text from an email from Lawrence Tabak (NIH) to Frances Collins (NIH), dated June 19, 2020, regarding the decision to shut down hydroxychloroquine trials early based on "conditional power analysis."
"Based on the recommendations from the DSMB that met late today, NHLBI is stopping the ORCHID clinical trial – this is the randomized controlled trial comparing hydroxychloroquine vs. placebo/Standard of care in hospitalized patients with confirmed SARS-CoV2 infection. This was a scheduled interim analysis – actually the 4th in a series – looking at both safety and outcomes data. Bottom line: There was no harm signal. However, based on the conditional power analysis there is less than a 1% probability that HCQ would prove more effective than standard of care even if we enrolled twice the number of patients. Therefore, we are concurring with the DSMB’s recommendation and stopping the trial in accordance with standard trial monitoring and oversight practices. The trial was almost completed (475 patients enrolled out of 510 target); however, based on these results there is no need to continue the study."
I would surmise that the statistical analysis plan (SAP) had a Bayesian conditional stopping rule for ending the trial such that when they did the interim analysis they decided that there were not enough events to continue the trial. If their analysis was scientific then it would have been based on the conditional probability of seeing a treatment effect of X% conditional on the number of events seen thus far in the Hydroxy arm vs placebo based on binomial probabilities. Whether that analysis was scientific or political is a very different question.
Thanks for the explanation. I suppose what bothers me is that they shut it down early without publishing the data, so we can't check their math. Do you think that the ORCHID data is subject to the Freedom of Information Act?
Interesting article Charles, but I don't think they are blind. At Vanderbilt they have done enough research projects it should have become evident pretty quickly that one therapy was causing death and one therapy was improving the patient's condition. The problem is that all of the educational programs have been captured by the liberal woke gestapo and are turning out a generation of robots who march in lockstop to orders. This week I received my quarterly newsletter from my state nursing association. Even though I retired my license in 2020, I'm still on the mailing list. It talked about how they are now lobbying the state legislature to pass three main bills. #1 - Workplace safety and violence prevention. #2 - Decriminalization of nurses. #3- Nursing shortage. My head about exploded. First of all, workplace safety and violence? Where is the data that nurses are being attacked in the hospitals? Why have they suddenly become the victims? If there has been an increase in violence maybe it's because they isolated patients from their families, threatened them with arrest by the police and violated patient's basic civil rights. Second, decriminalization of nurses? They say this is needed because criminalization of medical errors causes a decrease in reporting. They also say this would not free them from liability due to misconduct or civil liability. No, the federal government did that for them so they could freely murder without any worries about being held responsible. Unbelieveable. And finally, the nursing shortage. They state since the pandemic there is a critical shortage that is greater than even projected in 2014. Gee, I wonder why? Couldn't be that vaccine mandate they went all in on could it? Or maybe the nurses who were independent thinkers refused to be a part of the genocide they saw being carried out. Either way, you reap what you sow. So here you have the "leaders" of the statewide nurses so lacking in self-awareness that they can't even see how they have contributed to their own problems. They also included a quote from a Gallup poll that stated the nursing profession scored the highest assessment when it comes to ethics and honesty. What they failed to include is that assessment has dropped 10 points from it's highest rating in 2020. I hope they do try to push through the bill giving them protection from criminal liability. I will be the first one to line up and testify against passage of the bill, and I will make sure I will have plenty of other witnesses there with me.
Thank you. God bless you.
You know, I'm still giving reasonable doubt to some of the lower level employees in all of this, but if they knew they were killing people, that's just illegal and there is a price to be paid for it. Thank you for your perspective.
I will say that my daughter said there was one nurse that worked the last night she was there who was sweet and kind and when she brought in the Remdesivir and tried to give it my daughter said 'No, I don't want that" forcefully to her, she said, OK, that's fine and laid it down and didn't even question it. She was also the first nurse in 3 days to ask her about washing up or if her sheets had been changed or freshened up and that actually spent time with her. One day she went 10 hours without seeing a nurse. She told the nurse before she left her room she was the only one on that floor that actually acted like she cared about patients. So it may not take everyone to be evil, but enough of them to start the crime and the rest may not realize they are accessories. The one disconnect we did find was between the nursing staff and Respiratory therapy staff. Nursing kept turning her oxygen up to ridiculous, uncalled for amounts and at one point had her on 15 liters and told her the next step was a ventilator because she couldn't go any higher with a regular face mask. Now mind you she was not short of breath, could take it off herself and get up and walk to the bathroom just fine. They had ordered a nebulizer on admission and 2 days later it still had not been given to her. She hadn't seen a Respiratory therapist in over 36 hours. Well , it just so happened her boss was really good friends with the CEO of the hospital and had told her if she needed anything at all to let him know. I told her it was time to play that card so she called him. Within 5 minutes she had 2 RT supervisors in her room and that's when things began to turn around. They got her nebulizer set up (which nursing had never sent the order through), they turned her monitor around so she could see what her oxygen level was running and they turned her O2 back down to 6 liters because her levels were in the 90's. In fact ,one of the RT supervisors was stunned they had her on that much oxygen. She told him she had been asking the nurses to turn it down but they said they were only allowed to turn it up not down. He told her that wasn't true. So Respiratory Therapy certainly knew that something wasn't right. But whether they thought it was just people bad at their job or more sinister is hard to say. But these 2 individuals helped save her life. Because she could now monitor her oxygen level, I was able to have her start weaning off the oxygen and that's how we were able to get her to walk out of there AMA. I had lunch with a couple of nurse friends I worked with for years a few months ago. We were so close for years, and knew each other's most intimate secrets, our children were all the same ages and played together. I trained them when they first started so they've always considered me their mentor. I've supported one of them through a divorce, you know the kind of friends you may not see for 5 years, but then when you see again it's like you haven't been apart for a day. They both still work part time in the hospitals. As I began to tell them about our experience in the hospital, they looked at me with their mouths open like I had grown a second head. I could tell they thought I must be making this up, it couldn't have happened like I was saying. I left with a profound sadness that day, because I knew nothing would ever be the same again. Then I remembered something one of them had said the previous time we had met before this. She had said how they were offering such big bonuses to get nurses to work extra shifts. Then she said, they even gave us all $50 Kroger gift cards just to be nice, and was almost giddy when she said it. Yeah, I thought, how many patients did they have to murder to pay for those. It was obvious she didn't have a clue.
So well written. I am a nurse as well. I am retired and I am ashamed of my profession who stood by and watched these patients die. I don’t know how they can live with themselves when innocent, sick people only came for help. It will take years for people to trust nurses and doctors again.
Interesting idea of "no one blind" comparisons. Although the Pharmas would game that just like remdesivir v hydroxy. With the vaxxxes the trials and data were a total farce as per the Brook Jackson case. The reg agencies are totally captured! So all data are now pure jokes.
Hello Dr. Hay.
Let me ask you a question: What is conditional power analysis, and how do you think it was used in the context referenced in the ORCHID hydroxychloroquine trials at Vanderbilt? Here is the text from an email from Lawrence Tabak (NIH) to Frances Collins (NIH), dated June 19, 2020, regarding the decision to shut down hydroxychloroquine trials early based on "conditional power analysis."
From page 165 of 201 of this .pdf: https://www.judicialwatch.org/wp-content/uploads/2022/03/JW-v-HHS-Collins-Comms-Prod-4-02302.pdf
"Based on the recommendations from the DSMB that met late today, NHLBI is stopping the ORCHID clinical trial – this is the randomized controlled trial comparing hydroxychloroquine vs. placebo/Standard of care in hospitalized patients with confirmed SARS-CoV2 infection. This was a scheduled interim analysis – actually the 4th in a series – looking at both safety and outcomes data. Bottom line: There was no harm signal. However, based on the conditional power analysis there is less than a 1% probability that HCQ would prove more effective than standard of care even if we enrolled twice the number of patients. Therefore, we are concurring with the DSMB’s recommendation and stopping the trial in accordance with standard trial monitoring and oversight practices. The trial was almost completed (475 patients enrolled out of 510 target); however, based on these results there is no need to continue the study."
I would surmise that the statistical analysis plan (SAP) had a Bayesian conditional stopping rule for ending the trial such that when they did the interim analysis they decided that there were not enough events to continue the trial. If their analysis was scientific then it would have been based on the conditional probability of seeing a treatment effect of X% conditional on the number of events seen thus far in the Hydroxy arm vs placebo based on binomial probabilities. Whether that analysis was scientific or political is a very different question.
Thanks for the explanation. I suppose what bothers me is that they shut it down early without publishing the data, so we can't check their math. Do you think that the ORCHID data is subject to the Freedom of Information Act?
I have no idea. It seems like the FDA doesn’t release information that doesn’t benefit big Pharma but go for it if you want!
I'm seriously thinking about it.