Dr. Urso's and Dr. Young's comments revisited after an encouraging start to Ivermectin and Cancer community trials
The difference between the Calu and Vero cells and the results are clearly explained in the paper, and it has nothing to do with cancer. It has to do with TMPRSS2 expression, positive (+) or negative (-). Engineered TMPRSS2 (+) Vero cells showed the same ineffectiveness with Calu cells which are also TMPRSS2 (+.) Chloroquine is effective with TMPRSS2(-) Vero Cells
“Moreover, chloroquine and hydroxy- chloroquine inhibited S-driven entry into TMPRSS2− Vero cells with high efficiency whereas the inhibition of entry into TMPRSS2+ Calu-3 and TMPRSS2+ Vero cells was inefficient and absent, respectively (Fig. 1a and Table 1).
Therefore, chloroquine and hydroxychloroquine can block S-driven entry, but this inhibition is cell-line-dependent and efficient inhibition is not observed in TMPRSS2+ lung cells.”
Dots have been connected. Thank you for looking into explaining the connections.
On the idea that viruses are repair proteins: We are not made of DNA. We are made of proteins that our DNA has the messages to make. The messages are in DNA gene segments that mRNA is transcribed from. The mRNA then translates into proteins. When a necessary new protein needs to be made that will change cellular functions in our bodies, the message to make it has to come from somewhere other than the DNA we were born with. It could be that the messages are in these virus particles that come from nature that we are meant to communicate with. That's why we have receptors for them to attach. Unfortunately, man thinks he can outsmart God by altering these virus particles to allow the production of our own manmade proteins. These manmade instructions can get permanently installed into the human genome, and this is dangerous. We are already witnessing the consequences.
Hi Charles, we were discussing this just now. Genervter and myself found papers correlating viral (& vax!) response with pro tumor signalling pathways.
IVM targets several different protumor & viral pathways.
I keep away from the viruses aren't real brigade, I've seen lots of handwaving but all the convincing evidence right down to TEM imaging is on the other side.
Transcription factor E2F1 positively regulates interferon regulatory factor 5 expression in non-small cell lung cancer
...Interferon regulatory factor 5 (IRF5), a member of the interferon regulatory factor (IRF) family with diverse roles, is commonly found in malignant tumors.3 However, the expression of IRF5 in tumor is inconsistent and even the opposite. In some types of human cancers, the expression of IRF5 is upregulated, and it can promote its development, leading to a poor prognosis. On the contrary, it is a different story in some other types of cancers.4 It is reported that the expression of IRF5 is reduced in gastric cancer, renal cancer, and is associated with the progression and metastasis of breast cancer.
E2F8 as a Novel Therapeutic Target for Lung Cancer
BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant
SARS-CoV-2 infection activates interferon-controlled signaling pathways and elicits a wide spectrum of immune responses and clinical manifestations in human patients.
...We found that vaccinated patients demonstrated enrichment in p53 regulated cell cycle arrest genes, specifically CCNA1, E2F8, and E2F1 (Fig. 2a, i), consistent with a possibility of higher p53 activity levels in the vaccinated patients. Interestingly E2F8, but not CCNA1 or E2F1, was modestly upregulated 7 days post-vaccination in the naïve vaccinated individuals (1.5-fold, padj = 0.04).
Back on twitter: @doorlesscarp
Young is wrong.